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T緇嗚優(yōu)媧誨寲鐨勬爣蹇楀簲璇ユ槸寰楀埌涓や釜媧誨寲淇″彿
媧誨寲淇″彿1鏄疶緇嗚優(yōu)鍙椾綋TCR涓庣浉搴旂殑鎶楀師鑲?MHC鍒嗗瓙緇撳悎錛岋紙榪欓噷瑕佹敞鎰忥紝CD4+緇嗚優(yōu)涓庢姉鍘熻偨-MHC II綾誨垎瀛愮粨鍚?CD8+緇嗚優(yōu)涓庢姉鍘熻偨-MHC I綾誨垎瀛愮粨鍚堛侰D4銆丆D8鏄疶CR鐨勮緟鍔╁彈浣擄紝涔熷瓨鍦ㄤ簬T緇嗚優(yōu)琛ㄩ潰銆傦級緇撳悎鍚嶵CR-CD3澶嶅悎浣撴湁浜嗕俊鍙蜂紶瀵肩殑鑳藉姏錛孋D3澶嶅悎浣撶殑鑲介摼鑳?yōu)娴嗗尯鍐呭惈鏈塈TAM錛堝厤鐤彈浣撻叒姘ㄩ吀媧誨寲鍩哄簭錛夛紝ITAM鍙互鎶婃椿鍖栫殑淇″彿浼犲鑷崇粏鑳?yōu)鍐呴儴锛岃囅x寰楀埌媧誨寲淇″彿1
鍙湁媧誨寲淇″彿1榪樹笉鍙互浣縏緇嗚優(yōu)媧誨寲錛岃繖鏃墮渶瑕佹椿鍖栦俊鍙?
媧誨寲淇″彿2灝辨槸鐢辯粏鑳?yōu)琛ㄩ潰鐨勯粡闄勫垎瀛愭潵瀹屾垚鐨勩傚浜嶵緇嗚優(yōu)鏉ヨ錛孋D28鏄駭鐢熸椿鍖栦俊鍙風(fēng)殑鍏卞埡嬋鍒嗗瓙錛屽畠涓庝笌姝緇嗚優(yōu)鎺ヨЕ鐨凙PC(鎶楀師鍛堥掔粏鑳?yōu)锛夎〃闈㈢殑B7鍒嗗瓙緇撳悎鍚庯紝鍗沖彲浜ф媧誨寲淇″彿錛屾涓虹浜屾椿鍖栦俊鍙楓傦紙闇瑕佽鏄庣殑鏄紝濡傛灉CD152涓嶣7緇撳悎錛屼駭鐢熺殑鍗存槸鎶戝埗淇″彿錛屽洜涓篊D152鑳?yōu)鍐呭尯鍚湁ITIM錛堝彈浣撻叒姘ㄩ吀鎶戝埗鍩哄簭錛?錛?br />
3錛庢姉鍘熸竻闄ら樁孌碉紙antigen-eliminatingphase錛夋槸鍏嶇柅鏁堝簲緇嗚優(yōu)鍜屾姉浣撳彂鎸ヤ綔鐢ㄥ皢鎶楀師鐏椿騫朵粠浣撳唴娓呴櫎鐨勬椂鏈燂紝涔熺О鏁堝簲闃舵銆傝繖鏃跺鏋滆瀵煎厤鐤簲絳旂殑鎶楀師榪樻病鏈夋秷澶憋紝鎴栬呭啀嬈¤繘鍏ヨ嚧鏁忕殑鏈轟綋錛屾晥搴旂粏鑳?yōu)鍜屾姉浣摓兗?strong>涓庢姉鍘熷彂鐢熶竴緋誨垪鍙嶅簲銆?/strong>
鎶椾綋涓庢姉鍘熺粨鍚堝艦鎴愭姉鍘熷鍚堢墿錛屽皢鎶楀師鐏椿鍙婃竻闄わ紱T鏁堝簲緇嗚優(yōu)涓庢姉鍘熸帴瑙﹂噴鏀懼縐嶇粏鑳?yōu)鍥犲瓙锛岃鍙戝厤鐤値鐥囧Q汣TL錛圱緇嗚優(yōu)鐨勬晥搴旂粏鑳?yōu)锛尀鏄疌D8+T緇嗚優(yōu)錛夌洿鎺ユ潃浼ら澏緇嗚優(yōu)銆傞氳繃浠ヤ笂鏈哄埗錛岃揪鍒版竻闄ゆ姉鍘熺殑鐩殑銆?/span>